evaluation of in vitro cytotoxic effects of juniperus foetidissima and juniperus sabina extracts against a panel of cancer cells
نویسندگان
چکیده
isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. it has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. here branchlets and berries of juniperus foetidissima and j. sabina were collected, dried and ethanol extracts of them obtained using percolation. extracts were dried in reduced pressure and cytotoxic effects of different concentrations (5, 10, 20 ?g/ml) were evaluated by mtt assay against three tumor cell lines (hela, kb, mda-mb-468), using elisa at 540 nm. the extracts of the branchlets of male and female of j.foetidissima and berries extract of j. sabina showed inhibitory activities against kb cells. extracts of male branchlets of j. foetidissima and berries extract of j. sabina were cytotoxic (cell survival less than 50%) against hela cell line. regarding to mda-mb-468, only the extract of male branchlets of j. foetidissima was cytotoxic. extracts of j. sabina were not cytotoxic at tested concentrations. according to the results obtained by mtt assay, kb cells seem to be much more sensitive than the other cell lines.
منابع مشابه
Evaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima and Juniperus sabina Extracts Against a Panel of Cancer Cells
Isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. It has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. Here branchlets and berries of Juniperus foetidissima and J. sabina were collected, dried and ethanol extracts of them obtain...
متن کاملEvaluation of In Vitro Cytotoxic Effects of Juniperus foetidissima and Juniperus sabina Extracts Against a Panel of Cancer Cells
Isolation of some potent anti-tumor compounds from medicinal plants has motivated researchers to screen different parts of plant for their anti-tumor effects. It has been reported that several species of conifers posses’ cytotoxic activities on some tumor cell lines. Here branchlets and berries of Juniperus foetidissima and J. sabina were collected, dried and ethanol extracts of them obtain...
متن کاملComparative Analysis of Chemical Profile, Antioxidant, In-vitro and In-vivo Antidiabetic Activities of Juniperus foetidissima Willd. and Juniperus sabina L.
Fruit and leaves of junipers are commonly used internally as tea and pounded fruits are eaten to lower blood glucose levels in Anatolia. Thus, we aimed to evaluate antidiabetic and antioxidant potential and the chemical profile of Juniperus foetidissima Willd. and J. sabina L. in this study. In-vitro antidiabetic activities of leaf and fruit extracts were examined by their inhibitory activity o...
متن کاملComparative Analysis of Chemical Profile, Antioxidant, In-vitro and In-vivo Antidiabetic Activities of Juniperus foetidissima Willd. and Juniperus sabina L.
Fruit and leaves of junipers are commonly used internally as tea and pounded fruits are eaten to lower blood glucose levels in Anatolia. Thus, we aimed to evaluate antidiabetic and antioxidant potential and the chemical profile of Juniperus foetidissima Willd. and J. sabina L. in this study. In-vitro antidiabetic activities of leaf and fruit extracts were examined by their inhibitory activity o...
متن کاملIn Vitro Cytotoxicity of Two Subspecies of Juniperus excelsa on Cancer Cells
Objective(s) The cytotoxic effects of crude ethanol extracts of some previously tested Iranian conifers on tumor cell lines have motivated us to screen different parts of two subspecies in these genus. Materials and Methods Terminal branchlets and berries of Juniperus excelsa subsp. excelsa and J. excelsa subsp. polycarpos were collected, dried and extracted with ethanol/H2O (80/20 v/v) via pe...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۲۰۰۹، شماره ۱۰، صفحات ۲۸۱-۲۸۶
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